Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Title: Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
Creator: Zhang, Qisi; Kounde, Cyrille S.; De Vita, Elena; Kozakov, Dima; McCluskey, Adam; Harling, John D.; Fuchter, Matthew J.; Tate, Edward W.; Mondal, Milon; Greenfield, Jake L.; Baker, Jennifer R.; Kotelnikov, Sergei; Ignatov, Mikhail; Tinworth, Christopher P.; Zhang, Leran; Conole, Daniel
Relation: Chemical Communications Vol. 58, Issue 78, p. 10933-10936
Publisher Link: http://dx.doi.org/10.1039/d2cc03092f
Publisher: Royal Society of Chemistry
Resource Type: journal article
Date: 2022
Description: Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.
Subject: proteolysis targeting chimeras (PROTACs); protein expression; protein degradation; controlled degradation
Identifier: http://hdl.handle.net/1959.13/1482782
Identifier: uon:51022
Identifier: ISSN:1359-7345
Language: eng
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